There are various flavonoid compounds found naturally in fruits and vegetables. They have been gaining attention for their potential health benefits, particularly in anti-aging. Fisetin is a plant pigment belonging to the flavonoid group of polyphenols. It can be found in various fruits and vegetables, including strawberries, apples, onions, cucumbers, and persimmons. It is also available as a dietary supplement.
It has been found to have several potential health benefits, including anti-inflammatory, antioxidant, and anti-cancer effects. This article will explore how it can benefit as one ages.
Benefits for Anti-Aging
As you age, your cells experience damage from various sources, including oxidative stress, inflammation, and DNA damage. Over time, this damage can accumulate, leading to cellular dysfunction and, ultimately, age-related diseases. The best fisetin supplements have been found to have several properties that may help to mitigate this damage and promote healthy aging.
Anti-inflammatory effects
Chronic inflammation contributes to age-related diseases like heart disease, diabetes, and Alzheimer’s. This flavonoid has been found to have potent anti-inflammatory effects, which may help to reduce the risk of developing these diseases.
One study inhibited the production of pro-inflammatory cytokines in human cells. In another study, mice fed a high-fat diet supplemented with this flavonoid had reduced inflammation levels and oxidative stress levels in their livers.
Antioxidant effects
This flavonoid compound has been found to have potent antioxidant effects, which may help to mitigate the damage caused by oxidative stress. It protects human skin cells from oxidative stress induced by UV radiation. In another study, mice fed a high-fat diet supplemented with this compound had reduced levels of oxidative stress in their livers.
Anti-cancer effects
Cancer is a disease indicated by uncontrolled growth and proliferation of abnormal cells. This flavonoid compound has been found to have anti-cancer effects, which may help prevent cancer development and progression.
One study stated that this compound was found to inhibit the growth of human breast cancer cells in vitro. In another study, this flavonoid inhibited the growth and proliferation of prostate cancer cells in mice.
Neuroprotective effects
As one ages, the risk of developing neurodegenerative diseases such as Alzheimer’s and Parkinson’s increases. This flavonoid has been found to have neuroprotective effects, which may help to reduce the risk of developing these diseases.
In one study, fisetin improved cognitive function in mice with Alzheimer’s disease. In another study, it was found to protect dopaminergic neurons in mice with Parkinson’s disease.
Longevity effects
The ultimate goal of anti-aging research is to increase lifespan and health span. While the mechanisms behind aging are complex and not fully understood, this flavonoid has been found to have potential longevity effects.
One study stated that it increased the lifespan of fruit flies by up to 30%. While more research is needed to determine if it has similar effects in humans, these results are promising.
Summing Up
Fisetin is a potentially beneficial compound for anti-aging. Its anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and longevity effects make it an attractive target for research into age-related diseases. It’s important to note that while it has shown promise in preclinical studies, more research is needed to determine its safety and efficacy in humans. Additionally, its supplements may interact with certain medications or have adverse effects in specific populations, so it’s always important to consult a healthcare provider before starting any new supplement regimen.
